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How many watts do you need for a 110g? Am I going to need multiple heaters?
The tank is 48" long x 31" tall x 18" wide if that matters.

Going by the general rule of thumb of 5 watts per gallon, you'll need approximately 550 watts of heating for your tank. Given that it's a tall tank rather than long, you could skate by with 2 200-250 watt heaters on each end of the tank by the filters and be ok.

If your house is generally cold or has a lot of air movement, or your hood doesn't fit well, you'd be better off getting two 300 watters, one for each side. If your house is warm and you have a good top, the former would be ok.

One on each side provides better heat dispersion for less cool spots, and also a temporary backup if one fails. Also, two heaters will lessen the stress on a single heater, proving to make them last longer

Thank you very much.

anytime